So Madara formed Konohagakure (the hidden leaf village) with his best buddy Hashirama. In doing so they bring their two clans together the Uchiha clan (Madara) and the Senju clan (Hashirama). These two clans have faught for generations (starting with the two sons of the sage of six paths; each founding the respective clans after a . . . scuffle and differnce in ideals) but are puting their long history of warring behind them. Sadly for Madara their creation of Konohagakure was a failure, he realised this and was honestly right. He labeled it a failure when the ruiling body of the village was composed of the Senju clan, when Hashirama became the first Hokage, knowing that his brother Tobirama would be next.

He recognized that his people the Uchiha clan would not be safe (looking at Naruto (show not person) he was right) that given time they'll be no more. This alongside his reading of the Uchiha stone tablet is what puts him on track to crave project tsukuyomi.

Moving past Madara you have someone like Orochimaru (of All people) confirming that yes Tobirama and the things he did as Hokage only aided in further marginalizing the Uchiha clan. (Link Madara was completely right, what he feared Happened, there is no Uchiha almost directly cause of Tobirama (the for real not for real for real Uchiha hater dawg was racist and acted like he wasn't))

Whether Tobirama did it purposely or not (dawg looking mad stupid up top which is funny cause he's a highly intellgent man having fathered many forbidden ninjutsu and expanding on the HiddenLeaf) his actions are apart of what caused the Uchiha to become marginalized. The Uchiha clan a foundational part of Konohagakure alongside the Senju; gone one night after 4 Hokages (Senju still exists but like we don't care about them so . . . ). By the time of Naruto's very lonely childhood the Uchiha are ready to do something, anything, meeting in secret as a clan pushing for power in the Village's government deeply aware of their history and treatment. Like yes they were planing a coup, but ideally it should've never gotten this far. A coup if it happened could've ended by simply listening to them and acting right? Like I am naive but am I wrong? They didn't want to destroy the leaf, they just wanted representation, a say in things involving them.

Danzo is a Bitch, no argument. He clearly graduated from the school of Tobirama with how he views the Uchiha. Which is funny cause man was out here stealing their eyes, so like he hates them but loves their power. During his time as the leader of the Anbu he tried to push Hiruzen (During his second term as Hokage) to "swiftly" deal with the Uchiha issue. He wanted violance and clearly got what he wanteed whilst using an Uchiha, Itachi Uchiha to do it.

Itachi who's been operating withing the Anbu for almost his whole life who now is tasked with killing his mother and father aka current head of the Uchiha clan Fugaku Uchiha (The whole thing is sad espically when his parents sat there waiting for him, accepting their fates and the path their son chose. Like their last words were to take care of Sasuke) alongside the rest of their clan.

It should not have come to this